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?；蛆Z去氧膽酸 |
| CAS No.: |
516-35-8 |
| 分子式： |
C26H45NO6S |
| 分子量： |
499.7 |
| 備注： |
中文名稱?；蛆Z去氧膽酸中文同義詞?；蛆Z去氧膽酸標(biāo)準(zhǔn)品;?；蛆Z去氧膽酸;TAUROCHENODEOXYCHOLICACID?；蛆Z去氧膽酸英文名稱:2-[4-(3,7-DIHYDROXY-10,13-CAS號(hào):516-35-8分子式:C26H45NO6S分子量:499.7含量98%白色粉末?；蛆Z去氧膽酸鈉用于生化研究;純天然?；蛆Z去氧膽酸含量98%白色粉末中文同義詞:?；蛆Z去氧膽酸;【純天然牛磺鵝去氧膽酸】醫(yī)藥含量95%白色粉末;純天然?；蛆Z去氧膽酸;【純天然?；蛆Z去氧膽酸】醫(yī)藥含量98%白色粉末;牛磺鵝去氧膽酸?,99.5%英文名稱Taurochenodeoxycholicacid英文同義詞2-(4-(3,7-dihydroxy-10,13-diMethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanaMido)ethanesulfonicacid;Taurocholicchenodeoxycholicacid;2-((R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonicacid;Taurochenodeoxycholicacid,99.5%;2-{[(3alpha,5beta,7alpha,20xi)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonicacid;2-[4-(3,7-dihydroxy-10,13-;Taurochenodeoxycholicacid;C05465CAS號(hào)516-35-8分子式C26H45NO6S分子量499.7EINECS號(hào)相關(guān)類別原料藥;醫(yī)藥原料;中藥對(duì)照品;對(duì)照品、標(biāo)準(zhǔn)品;其他原料;對(duì)照品;植物提取物;標(biāo)準(zhǔn)品;分析試劑標(biāo)準(zhǔn)品;對(duì)照品-中藥對(duì)照品;標(biāo)準(zhǔn)品-中藥標(biāo)準(zhǔn)品;標(biāo)準(zhǔn)品，對(duì)照品;分析試劑標(biāo)準(zhǔn)品;Intermediates&FineChemicals;Metabolites&Impurities;Pharmaceuticals;SteroidsMol文件516-35-8.mol結(jié)構(gòu)式?；蛆Z去氧膽酸性質(zhì)熔點(diǎn)186-200°C密度1.216±0.06g/cm3(Predicted)儲(chǔ)存條件Sealedindry,RoomTemperature溶解度可溶于氯仿、甲醇形態(tài)固體酸度系數(shù)(pKa)1.42±0.50(Predicted)顏色白色至淺棕色?；蛆Z去氧膽酸用途與合成方法生物活性Taurochenodeoxycholicacid(12-Deoxycholyltaurine)是動(dòng)物膽汁酸的主要生物活性物質(zhì)之一。TaurochenChemicalbookodeoxycholicacid可誘導(dǎo)細(xì)胞凋亡(apoptosis)，并具有明顯的抗炎和免疫調(diào)節(jié)作用。靶點(diǎn)HumanEndogenousMetabolite體外研究Taurochenodeoxycholicacid(12-Deoxycholyltaurine)dramaticallyimprovestheapoptosisrateofNR8383cellsinaconcentration-dependentmanner.Inthemeantime,TaurochenodeoxycholicacidsignificantlyaugmentsPKCmRNAlevels,activitiesandincreasesJNK,caspase-3andcaspase-8mRNAexpressionlevels,activities.體內(nèi)研究Taurochenodeoxycholicacid(12-Deoxycholyltaurine;0.05,0.1g/kg)decreasesthepulmonarycoefficientinthemodelmiceandreducesthepathologicaldamagesontheirlungs;itcandecreasetheexpressionlevelsofTNF-αandTIMP-2inpulmonarytissuesinthepulmonaryfibrosismiceandhasnosignificanteffectsonMMP2.Taurochenodeoxycholicacidsignificantlynormalizestheclinicalinflammatoryparameters,preventedindomethacin-inducedincreasesinthebiliarycontentsofsecondarybileacidsandhydrophobicityindex,andtendedtoattenuatetheintestinalinflammation.Taurochenodeoxycholicacidsignificantlysuppressespawswellingandpolyarthritisindex,increasesthelossbodyweightandindexofthymusandspleen,andamendsradiologicchangesinAArats.TheoverproductionandmRNAexpressionofTNF-α,IL-1βandIL-6areremarkablysuppressedinserumandsynoviumtissueofallTCDCA-treatedrats.化學(xué)性質(zhì)白色結(jié)晶體，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于動(dòng)物膽汁。用途用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。 |
| 結(jié)構(gòu)式： |
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聯(lián)系人： |
金經(jīng)理 |
地 址： |
湖北省武漢市東湖新技術(shù)開發(fā)區(qū)光谷大道41號(hào) |
郵 編： |
430000 |
電 話： |
18995560451 |
手 機(jī)： |
15102708508 |
傳 真： |
18995560451 |
Q Q： |
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www.hbdhchemical.com |
電子郵件： |
709783996@qq.com |
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